Nanostructured γ-Al2O3 Synthesis Using an Arc Discharge Method and its Application as an Antibacterial Agent against XDR Bacteria

In the last few years, many efforts have been devoted to investigating antibacterial activity of metal nanoparticles, especially against multidrug-resistant bacteria. Recently extensively drug-resistant (XDR) bacteria emerged and caused a global threat. The purpose this manuscript was synthesize nanostructured γ-Al2O3 as an agent some XDRs. results showed that Al2O3 mix rod spherical shapes in nano range with diameters less than 30 nm. zeta potential determined estimate surface charge for synthesized γ-Al2O3, which recorded −34 ± 1.8 mV, indicating good stability. potent Acinetobacter baumanii, inhibition zone diameter reached 19 mm minimum inhibitory concentration (MIC) value 2 µg/mL. observed prepared nanoparticles confirmed main mechanistic actions include bacterial cells apoptosis, ROS increment, cellular membrane disruption, DNA damage. cytotoxic effect (CC50) γ-Al2O3-NPs 1250 µg/mL normal human lung fibroblast cell line (WI-38 cells). It can be concluded had acceptable toxicity, may pave way its use fight XDR